Pharma Licence Test 5

1. Which of the following is the best description of a semipermeable membrane in the context of osmosis?

A membrane that allows neither solute nor solvent particles to pass through it.

A membrane that allows solute particles, but not solvent particles, to pass through it.

A membrane that allows solvent particles, but not solute particles, to pass through it.

A membrane that allows both solute and solvent particles to pass through it.

2. A cell is bathed is a solution that has a greater osmolarity than that of the cytosol. This solution is best described as which one of the following?

Isotonic

Hypertonic

Hypotonic

None of the above

3. What is the typical osmolarity of physiological fluids?

300 Mosmol L-1

0.3 mosmol L-1

300 osmol L-1

0.3 osmol L-1

4. Which one of the following is not an essential component of an osmotic pump drug delivery tablet?

Contain an active pharmaceutical ingredient (API)

Contain a single chamber

Coated with a semipermeable membrane

Have a orifice in the tablet coating

5. What is the aim of Structure Activity Relationship (SAR)?

Identify which functional groups are important for binding and/or activity

Defines the relative position of the binding groups

Important to drug design

Find a lead compound

6. What are the functions of pharmacophore EXCEPT?

Defines the important groups involved in binding

Need to know Active Conformation

Important to drug design

Alter, remove or mask a functional group

7. Which are the possible effects of Carboxylic Acids?

Possible binding interactions as free acid

Charged oxygen atoms are strong HBA’s

Reduction removes carbonyl oxygen as potential HBA and prevents ionization

All of the above

8. What is meant by a lead compound in medicinal chemistry?

A drug containing the element lead.

A leading drug in a particular area of medicine.

A compound that acts as the starting point for drug design and development.

A drug which is normally the first to be prescribed for a particular ailment.

9. Which of the following needs to be established before the search for a lead compound takes place?

the pharmacophore

Structure-activity relationships

a bioassay

patents

10. What is the term used for the automated in vitro testing of large numbers of compounds using genetically modified cells?

robotic testing

multiscreening

high throughput screening

nanotechnology

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